Endocrine Abstracts

Differentiated thyroid carcinoma represents a small percentage of human carcinomas. However, it is the commonest endocrine neoplasm and if diagnosed and treated properly does not affect the long-term survival of the patients.Aim: The aim was to study differentiated thyroid carcinoma affecting young adults.Patients and methods: All patients presenting with thyroid carcinoma to the department from 01.01.2002 to 31.12.2008 were review...

BackgroundRecent knowledge implicates a differential expression of the insulin-like growth factor-1 (IGF-1) mRNA splice variants (i.e., IGF-1Ea, IGF-1Eb and IGF-1Ec) in cancerous tissues, implying possible specific roles of the encoded IGF-1 protein isoforms in cancer biology. In particular, there is growing evidence that IGF-1Ec isoform may plays a distinct biological role in various types of cancer. The aim of the present study was to investigate wheth...

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

Introduction: IgG4-related thyroiditis (IgG4-RTD) is a rare fibroinflammatory disorder. It is characterized by dense lymphocyte infiltration (mainly IgG4+ plasma cells), enlargement and dysfunction of the thyroid gland. IgG4-RTD includes mostly cases of Hashimoto’s (HT) but also of Riedel’s and Graves’ thyroiditis. Diagnosis is set according to imaging and histopathological criteria. Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer (~9...

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98 years on LT4Rx witho...

Objective: Glycemic control of patients with type 1 diabetes is mainly based on insulin administration. The ongoing technological developments in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) provide new treatment strategies, with better glycemic control. This study assessed the clinical impact of two treatment strategies in adults with type 1 diabetes (T1D): multiple daily insulin injections (MDII) vs continuous subcutaneous insulin i...

Background: In the last decade, the combination of the widespread use of streptavidin-biotin technology and biotin–containing supplements (BCS) in the daily clinical practice, have led to numerous reports of erroneous hormone immunoassay results. However, there are no studies assessing the clinical and biochemical significance of that phenomenon, when treating patients with hypothyroidism. Therefore, a prospective study was designed to investigate the potential alteration...

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

Introduction: A significant body of literature supports that 25(OH)vitD deficiency is associated with insulin resistance. We studied the prevalence of 25(OH)vitD deficiency across the spectrum of glucose metabolism.Design: The study participants (441 total, 362 females (82.1%) and 79 males (17.9%)) had a mean age (±S.D.) of 64.59 (±9.44) years, range: 32–92 years. The study population was divided into two groups: Individuals...

Background and aims: To evaluate the evolution of thyroid cancer epidemiological characteristics from 2004 to 2014.Materials and methods: Retrospective analysis of histological data from thyroidectomies performed in our hospital in the period 2004–2014.Results: From 2004 to 2014, 2725 thyroidectomies (women 81% vs men 19%) were performed in our hospital. In 1083 of these (40%) histologic examination revealed thyroid cancer.</p...